Farooq HZ, James M, Abbott J, Oyibo P, Divall P, Choudhry N, Foster GR. Risk factors for hepatocellular carcinoma associated with hepatitis C genotype 3 infection: A systematic review. World J Gastrointest Oncol 2024; 16(4): 1596-1612 [PMID: 38660636 DOI: 10.4251/wjgo.v16.i4.1596]
Corresponding Author of This Article
Hamzah Z Farooq, MBChB, MRCP, MSc, Doctor, Research Fellow, Blizard Institute, Queen Mary University of London, 4 Newark Street, London E1 2AT, United Kingdom. hamzah.farooq@qmul.ac.uk
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
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Exclusions: HBV, HIV, age < 18 yr or > 70 yr, pregnancy, previous liver lesion, “extremely fragile”, low bodyweight (not defined), known mental health issues, patients who were taking phenytoin, rifampicin, carbamazepine, patients with pancytopenia
Table 4 Pooled individual participant data for all participants with hepatitis C genotype 3 who developed hepatocellular carcinoma
Risk factor
Number of participants
Patient-dependent factors
Cirrhosis
66
Male
118
Female
62
Age > 40 yr
65
Alcohol intake > 40 g/d
56
Anti-HBc
46
Diabetes
25
Age < 50 yr
0
NRAS oncogene
27
Age, per 10-yr increase
0
High BMI
5
Hypertension
3
HBV co-infection
12
Treatment dependent factors
DAA treatment
66
SVR achieved
74
SVR not achieved
13
Decompensated cirrhosis and achieved SVR
1
Use of SOF/DCV/RBV
9
Biochemical factors
Low platelet count
16
High AFP
65
High HCV VL
71
ALP > 68
65
HCV viraemia
58
MELD-score > 9.5
16
Citation: Farooq HZ, James M, Abbott J, Oyibo P, Divall P, Choudhry N, Foster GR. Risk factors for hepatocellular carcinoma associated with hepatitis C genotype 3 infection: A systematic review. World J Gastrointest Oncol 2024; 16(4): 1596-1612