Nie GL, Yan J, Li Y, Zhang HL, Xie DN, Zhu XW, Li X. Predictive model for non-malignant portal vein thrombosis associated with cirrhosis based on inflammatory biomarkers. World J Gastrointest Oncol 2024; 16(4): 1213-1226 [PMID: 38660630 DOI: 10.4251/wjgo.v16.i4.1213]
Corresponding Author of This Article
Xun Li, PhD, Chief Physician, Department of General Surgery, The First Hospital of Lanzhou University, No. 1 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. lxdr21@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
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World J Gastrointest Oncol. Apr 15, 2024; 16(4): 1213-1226 Published online Apr 15, 2024. doi: 10.4251/wjgo.v16.i4.1213
Table 1 Baseline of demographics and clinical characteristics of the patients
Characteristics
non-PVT (n = 286)
PVT (n = 286)
P value
Age [mean (SD)]
52.60 (11.61)
52.87 (12.02)
0.783
Sex, n (%)
Male
161 (56.30)
163 (57.00)
0.933
Female
125 (43.70)
123 (43.00)
BMI [mean (SD)]
22.71 (3.28)
22.70 (3.02)
0.952
Etiology, n (%)
AIH
40 (14.00)
20 (7.00)
0.001
Hepatitis
200 (69.90)
189 (66.10)
Others
46 (16.10)
77 (26.90)
Ascites, n (%)
No
154 (53.80)
60 (21.00)
< 0.001
Yes
132 (46.20)
226 (79.00)
GOV, n (%)
No
73 (25.50)
7 (2.40)
< 0.001
Yes
213 (74.50)
279 (97.60)
ALBI grade, n (%)
1
95 (33.20)
53 (18.50)
< 0.001
2
163 (57.00)
192 (67.10)
3
28 (9.80)
41 (14.30)
CTP, n (%)
A
106 (37.10)
58 (20.30)
< 0.001
B
136 (47.60)
145 (50.70)
C
44 (15.40)
83 (29.00)
Table 2 Baseline information on laboratory tests and inflammatory markers
Characteristics [mean (SD)]
non-PVT (n = 286)
PVT (n = 286)
P value
PLT
78.93 (48.65)
70.31 (60.19)
0.06
ALB
38.50 (6.87)
35.87 (6.21)
< 0.001
PT
14.80 (3.52)
16.41 (6.53)
< 0.001
PTA
71.29 (20.97)
63.24 (15.56)
< 0.001
INR
1.30 (0.32)
1.42 (0.45)
< 0.001
D-D
1.84 (2.75)
3.75 (5.42)
< 0.001
PVD
12.86 (2.34)
14.89 (3.34)
< 0.001
SVD
8.64 (2.90)
10.43 (3.50)
< 0.001
PVV
21.08 (5.34)
19.86 (6.19)
0.012
GLR
102.36 (189.29)
78.97 (97.41)
0.064
SII
258.89 (285.64)
298.02 (473.51)
0.232
ANRI
40.18 (70.91)
27.31 (46.83)
0.011
PNI
43.51 (7.67)
39.47 (6.60)
< 0.001
NLR
3.42 (3.23)
4.04 (3.21)
0.022
PLR
92.75 (74.60)
110.43 (77.54)
0.006
ALRI
107.63 (256.37)
77.70 (66.09)
0.056
Table 3 The results of univariate and multivariate analysis
Characteristics
Univariate analysis
Multivariate analysis
OR
CI
P value
OR
CI
P value
Etiology
AIH
Reference
Reference
Hepatitis
1.890
1.066-3.350
0.029
1.772
0.869-3.613
0.115
Others
3.348
1.749-6.408
0.000
2.893
1.309-6.395
0.009
Ascites
No
Reference
Reference
Yes
4.394
3.043-6.346
0.000
2.007
1.27-3.174
0.003
GOV
No
Reference
Reference
Yes
13.660
6.165-30.266
0.000
5.844
2.385-14.321
0.000
ANRI
< 48
Reference
Reference
≥ 48
0.418
0.257-0.677
0.000
0.457
0.249-0.839
0.011
INR
< 1.27
Reference
Reference
≥ 1.27
2.646
1.887-3.710
0.000
1.389
0.722-2.672
0.326
PLR
≤ 68.06
Reference
Reference
> 68.06
1.846
1.305-2.610
0.001
2.308
1.474-3.615
0.000
ALB, g/L
< 43
Reference
Reference
≥ 43
0.292
0.185-0.460
0.000
0.700
0.387-1.269
0.240
D-D, μg/mL
≤ 2.52
Reference
Reference
> 2.52
4.860
3.345-7.059
0.000
2.795
1.805-4.33
0.000
PLT, × 109/L
< 85
Reference
Reference
≥ 85
0.420
0.286-0.615
0.000
0.520
0.306-0.884
0.016
PT, s
< 14.4
Reference
Reference
≥ 14.4
2.458
1.755-3.442
0.000
1.279
0.67-2.441
0.456
PVD, mm
< 14.5
Reference
Reference
≥ 14.5
3.613
2.509-5.202
0.000
2.110
1.345-3.31
0.001
PVV, cm/s
< 20.05
Reference
Reference
≥ 20.05
0.515
0.369-0.718
0.000
0.640
0.424-0.965
0.033
SVD, mm
< 8
Reference
Reference
≥ 8
3.680
2.511-5.394
0.000
1.281
0.772-2.128
0.338
Table 4 The baseline of training and testing groups, n (%)
Characteristics
Training group (n = 402)
Testing group (n = 170)
P value
Etiology
AIH
44 (10.90)
16 (9.40)
0.572
Hepatitis
268 (66.70)
121 (71.20)
Others
90 (22.40)
33 (19.40)
Ascites
No
138 (34.30)
76 (44.70)
0.024
Yes
264 (65.70)
94 (55.30)
GOV
No
56 (13.90)
24 (14.10)
1.000
Yes
346 (86.1)
146 (85.90)
PLT
< 85
287 (71.40)
129 (75.90)
0.318
≥ 85
115 (28.60)
41 (24.10)
D-D
≤ 2.52
262 (65.20)
99 (58.20)
0.140
>2.52
140 (34.80)
71 (41.80)
PVD
< 14.5
253 (62.90)
114 (67.10)
0.398
≥ 14.5
149 (37.10)
56 (32.90)
PVV
< 20.05
196 (48.80)
89 (52.40)
0.487
≥ 20.05
206 (51.20)
81 (47.60)
ANRI
< 48
344 (85.60)
141 (82.90)
0.501
≥ 48
58 (14.40)
29 (17.10)
PLR
≤ 68.06
148 (36.80)
58 (34.10)
0.604
> 68.06
254 (63.20)
112 (65.90)
Citation: Nie GL, Yan J, Li Y, Zhang HL, Xie DN, Zhu XW, Li X. Predictive model for non-malignant portal vein thrombosis associated with cirrhosis based on inflammatory biomarkers. World J Gastrointest Oncol 2024; 16(4): 1213-1226