Does the discrepancy in histologic differentiation between a forceps biopsy and an endoscopic specimen necessitate additional surgery in early gastric cancer?

Table 3 Histopathological characteristics of surgical specimens n (%)

Variables	Discrepancy	Non-discrepancy	P value
Tumor size in the specimen (n = 265)
Median, cm (range)	3.0 (0.8-5.5)	2.2 (0.4-8.5)	0.252
Tumor staging (n = 265)
Ia	7 (28.0)	121 (50.4)	0.033
Ib	18 (72.0)	119 (49.6)
Nodal staging (n = 265)
Positive	6 (24.0)	19 (7.9)	0.009
Negative	19 (76.0)	221 (92.1)
Lymphatic invasion (n = 265)
Positive	7 (28.0)	41 (17.1)	0.177
Negative	18 (72.0)	199 (82.9)
Vascular invasion (n = 265)
Positive	2 (8.0)	17 (7.1)	0.697
Negative	23 (92.0)	223 (92.9)
Ki-67 (n = 243)
High	20 (95.2)	186 (83.8)	0.215
Low	1 (4.8)	36 (16.2)
p53 (n = 243)
Positive	15 (71.4)	138 (62.2)	0.401
Negative	6 (28.6)	84 (37.8)
HER2 (n = 243)
Positive (2+ and 3+)	7 (33.3)	41 (18.5)	0.102
Negative (0 and 1+)	14 (66.7)	181 (81.5)
EGFR (n = 243)
Positive	17 (81.0)	123 (55.4)	0.035
Negative	4 (19.0)	99 (44.6)

HER2: Human epidermal growth factor 2; EGFR: Epidermal growth factor receptor.