Macroscopic appearance of Type IV and giant Type III is a high risk for a poor prognosis in pathological stage II/III advanced gastric cancer with postoperative adjuvant chemotherapy

Table 2 Multivariate Cox proportional hazards model in pathological stage II/III advanced gastric cancer

Clinicopaghological factors	Classification	Number	Multivariate analysis for PFS (Hazard ratio)	Multivariate analysis for OS (95%CI)	P value	Hazard ratio	95%CI	P value
Age	Young	74	Reference		0.029	Reference		0.008
	Elderly	98	1.83	1.07-3.20		2.35	1.25-4.58
Sex	Male	120	Reference	1.06-4.34	0.031	Reference	0.87-4.91	0.11
	Female	52	2.05			1.93
Tumor location	Upper	54				2.84	1.24-7.19	0.013
	Middle	74				1.73	0.70-4.66	0.24
	Lower	44				Reference
13th JGCA pStage	II	57	Reference			Reference
	IIIA	79	6.17	2.42-20.83	< 0.0001	2.25	0.93-6.27	0.08
	IIIB	36	8.48	3.11-29.70	< 0.0001	4.81	1.79-14.72	0.002
Vascular invasion	v0	16				Reference
	v1	55				1.46	0.38-9.55	0.62
	v2	55				0.71	0.17-4.80	0.68
	v3	46				1.34	0.33-9.01	0.71
Macroscopic feature	High risk	18	2.29	1.06-4.63	0.036	2.74	1.17-6.15	0.021
	Average risk	154	Reference			Reference

JGCA: Japanese Gastric Cancer Association.