Macroscopic appearance of Type IV and giant Type III is a high risk for a poor prognosis in pathological stage II/III advanced gastric cancer with postoperative adjuvant chemotherapy

Table 1 Univariate prognostic analysis in pathological stage II/III advanced gastric cancer

Clinicopaghological factors	Classification	Number	Univariate analysis (5-yr RFS)	Univariate analysis (P value)	5-yr OS	P value
Age	Young	74	77.40%	0.0082	82.30%	0.0024
	Elderly	98	56.90%		58.10%
Sex	Male	120	62.50%	0.018	63.50%	0.0054
	Female	52	81.90%		83.10%
Tumor location	Upper	54	59.60%	0.12	81.10%	0.027
	Middle	74	68.40%		76.10%
	Lower	44	80.50%		59.20%
Method	Total	100	67.40%	0.51	69.00%	0.18
	Distal	72	70.00%		76.00%
Lymphadenectomy	D1	10	68.60%	0.95	56.00%	0.53
	D1+	16	64.30%		79.60%
	D2	146	69.00%		72.20%
Laparoscopic	Yes	25	77.30%	0.16	77.30%	0.2
	No	147	67.00%		70.90%
Splenectomy	Yes	51	61.50%	0.2	65.80%	0.31
	No	121	71.50%		74.50%
Transfusion	Yes	23	63.90%	0.58	68.00%	0.37
	No	149	69.30%		72.70%
13th JGCA pT	T2	65	80.30%	0.019	83.00%	0.021
	T3	105	61.90%		65.80%
	T4	2	50.00%		50.00%
13th JGCA pN	N0	24	90.50%	0.0043	89.40%	0.022
	N1	82	74.00%		77.30%
	N2	66	54.30%		59.10%
13th JGCA pStage	II	57	92.10%	< 0.0001	86.80%	< 0.0001
	IIIA	79	63.90%		76.00%
	IIIB	36	43.00%		42.80%
Lauren histology	Intestinal	60	63.60%	0.23	68.30%	0.27
	Diffuse	112	71.30%		74.20%
INF	Alpha	13	76.90%	0.83	84.60%	0.53
	Beta	75	69.90%		77.50%
	Gamma	84	66.40%		67.50%
Lymphatic invasion	ly0	9	100.00%	0.2	100.00%
	ly1	45	74.80%		77.10%	0.19
	ly2	62	63.70%		71.20%
	ly3	56	63.90%		63.60%
Vascular invasion	v0	16	87.10%	0.055	85.60%	0.043
	v1	55	69.90%		65.20%
	v2	55	72.80%		83.50%
	v3	46	55.70%		62.70%
Macroscopic feature	High risk	18	35.70%	0.0003	34.00%	< 0.0001
	Average risk	154	72.60%		76.60%

JGCA: Japanese Gastric Cancer Association.