Review
Copyright ©The Author(s) 2017.
World J Gastrointest Oncol. Apr 15, 2017; 9(4): 142-152
Published online Apr 15, 2017. doi: 10.4251/wjgo.v9.i4.142
Table 2 Abnormally methylated genes as potential circDNA blood-based colorectal cancer detection biomarkers
Potential biomarkersCRC sensitivity (%)CRC specificity (%)Ref.
ALX440-8370-82[67,76]
TFPI276-89-[77-80]
SDC292-[81]
RUNX365100[82,83]
NEUROG152-6491[84]
MGMT3996[74]
RARβ224100[74]
NGFR5184[85]
9-Sep48-9086-93[64-67,70,86]
TMEFF26569[85]
Vimentin5993[41]
RASSF2A58100[74]
Wif-17498[74]
APC6100[87]
hMLH14398[87]
HTLF21-3498-100[87,88]
SFRP26794[89]
CDKN2A/P1671100[83]
Panel: SEPT9, HLTF and ALX474-8890-96[68]
Panel: SEPT9 and ALX4--[67]
Panel: MGMT, RASSF2A, Wif-1 gene86.5-[74]
Panel: BMP3, NDRG4, vimentin, TFPI2, mutant KRAS and β-actin87-[69]
Panel: AGTR1, WNT2, SLIT278-[71]
Panel: CINP1, FBN1, INA, SNCA, MAL and SPG2090-99-[73]
Panel: CYCD2, HIC1, PAX5, RASSF1A, RB1 and SRBC8468[72]
Panel: THBD and C9orf507180[75]
RASSF1A, E-cadherin--[72,90]
CAHM--[91]
FRP2, TPEF/HPP1--[83,84,92]