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Copyright ©The Author(s) 2017.
World J Gastrointest Oncol. Mar 15, 2017; 9(3): 105-120
Published online Mar 15, 2017. doi: 10.4251/wjgo.v9.i3.105
Table 4 Somatic mutations found in the tumor suppressor gene MLH1 in gastrointestinal adenocarcinoma samples
SampleCancer typeCIMP classMutationMutation typeAA pos.Aff. AAsVEST score1
TCGA-A6-6780-01COADCIMP+chr3:37038192.G>AMissense substitution6710.994
TCGA-CA-6719-01COADCIMP+chr3:37067243.G>AMissense substitution38510.701
TCGA-CM-6171-01COADCIMP+chr3:37070349.C>-Frameshift deletion495262-
TCGA-EI-6917-01READCIMP+chr3:37058999.C>TMissense substitution26510.981
TCGA-BR-6452-01STADCIMP+chr3:37107356.A>G3' UTR---
TCGA-FP-A4BE-01STADCIMP+chr3:37090086.C>TNonsense substitution65998-
TCGA-A6-6138-01COADCIMPichr3:37035084.G>AMissense substitution1610.901
TCGA-AD-6889-01COADCIMPichr3:37053348.->AFrameshift insertion195562-
TCGA-AZ-6601-01COADCIMPichr3:37067242.C>TMissense substitution38510.952
TCGA-CM-4746-01COADCIMPichr3:37059062.A>-Frameshift deletion286471-
TCGA-EI-6884-01READCIMPichr3:37058995.A>GAcceptor splice site264493-
TCGA-BR-6802-01STADCIMPichr3:37053348.A>-Frameshift deletion195562-
TCGA-F1-6874-01STADCIMPichr3:37050312.ACCTTTTTTACAACATAGCC>-Frameshift deletion154603-
TCGA-A6-6781-01COADCIMP-chr3:37053348.A>-Frameshift deletion195562-
TCGA-CM-6674-01COADCIMP-chr3:37058999.C>-Frameshift deletion265492-
TCGA-F4-6856-01COADCIMP-chr3:37089123.GAA>-In-frame deletion6151-
TCGA-R6-A6KZ-01EACCIMP-chr3:37034874.T>C5’ UTR---
TCGA-CG-5723-01STADCIMP-chr3:37053550.G>-Frameshift deletion213544-