Regulation of CTNNB1 signaling in gastric cancer and stem cells

Figure 1 Main WNT/β-catenin pathway involved in cancer and stem cells. Wnt inhibits CTNNB1 phosphorylation by GSK3B, which leads to the transcription of pro-proliferation related genes via binding of CTNNB1 to TCF or LEF. P indicates phosphate. Red color shows molecules in pathways in cancer, whereas blue color shows molecules in signaling pathways regulating pluripotency of stem cells (KEGG). DVL: Dishevelled; TCF: T cell transcription factor; APC: Adenomatous polyposis coli.