Genetic polymorphisms of interleukin 1β gene and sporadic pancreatic neuroendocrine tumors susceptibility

Table 2 Genotype and allele frequencies of the interleukin 1β -511 C/T and +3954 C/T polymorphisms in pancreatic adenocarcinoma, pancreatic neuroendocrine tumor and intraductal papillary mucinous neoplasm patients and controls

	Controls (n = 98)	PDAC (n = 85)	P; OR (95%CI)	pNET (n = 51)	P; OR (95%CI)	IPMN (n = 19)	P; OR (95%CI)
-511 C/T
CC	44	35	1	13	1	6	1
CT	47	44	0.64; 1.18 (0.64-2.16)	31	0.04; 2.23 (1.04-4.81)	10	0.59; 1.56 (0.52-4.65)
TT	7	6	1; 1.08 (0.33-3.49)	7	0.04; 3.95 (1.13-13.84)	3	0.16; 3.14 (0.64-15.56)
CT + TT	54	50	0.37; 1.36 (0.75-2.44)	38	0.02; 2.38 (1.13-5.02)	13	0.32; 1.76 (0.62-5.03)
C allele	135	114	1	57	1	22	1
T allele	61	56	0.74; 1.09 (0.7-1.69)	45	0.03; 1.75 (1.07-2.86)	16	0.19; 1.61 (0.79-3.28)
+3954 C/T
CC	45	50	1	33	1	8	1
CT	44	28	0.08; 0.57 (0.31-1.07)	16	0.07; 0.49 (0.24-1.03)	10	0.79; 1.28 (0.46-3.54)
TT	9	7	0.59; 0.7 (0.24-2.04)	2	0.19; 0.3 (0.06-1.49)	1	1; 0.62 (0.07-5.64)
CT + TT	53	35	0.1; 0.59 (0.33-1.07)	18	0.04; 0.46 (0.23-0.93)	11	0.81; 1.18 (0.43-3.15)
C allele	134	128	1	82	1	26	1
T allele	62	42	0.16; 0.71 (0.45-1.12)	20	0.03; 0.53 (0.29-0.94)	12	0.85; 1.07 (0.51-2.25)

pNET: Pancreatic neuroendocrine tumor; PDAC: Pancreatic adenocarcinoma; IPMN: Intraductal papillary mucinous neoplasm.