Multitarget stool DNA for colorectal cancer screening: A review and commentary on the United States Preventive Services Draft Guidelines

Table 3 Burdens, harms, benefits, and efficiencies for 100% perfect adherence for colorectal cancer screening tests at current recommended intervals, ages 50-75, per 1000 people screened

		Burdens and harms			Benefits
CISNETmodel	Test	Stool tests	Total COL	Complications	LYG	CRC DA	CRC incidence reduction	CRC mortality reduction	% of COL 10y LYG	COL per LYG	Complications per LYG	Complications per DA
SimCRC	COL 10y	0	4007	14	275	24	81%	87%	100%	15	0.051	0.58
	FIT1y	15778	1739	10	260	23	67%	81%	95%	7	0.038	0.43
	hsFOBT1y	12914	2230	11	261	23	69%	82%	95%	9	0.042	0.48
	mt-sDNA3y	5990	1701	9	250	22	63%	78%	91%	7	0.036	0.41
MISCAN	COL 10y	0	4101	15	248	22	62%	79%	100%	17	0.060	0.68
	FIT1y	15843	1757	10	231	20	47%	72%	93%	8	0.043	0.50
	hsFOBT1y	12927	2287	11	232	20	49%	73%	94%	10	0.047	0.55
	mt-sDNA3y	5779	1714	9	215	19	43%	68%	87%	8	0.042	0.47
CRC-SPIN	COL 10y	0	4049	15	270	24	88%	90%	100%	15	0.056	0.62
	FIT1y	15444	1899	11	244	22	72%	81%	90%	8	0.045	0.50
	hsFOBT1y	13026	2253	11	247	22	75%	82%	92%	9	0.045	0.50
	mt-sDNA3y	5927	1827	10	226	20	68%	76%	84%	8	0.044	0.50

CISNET: National Cancer Institute’s Cancer Intervention and Surveillance Modeling Network; SimCRC: Simulation model of colorectal cancer; MISCAN: Microsimulation screening analysis; CRC-SPIN: Colorectal cancer simulated population model for incidence and natural history; COL: Colonoscopies; LYG: Life-years gained; DA: Deaths averted; COL 10y: Colonoscopy at a 10-year interval.