Multitarget stool DNA for colorectal cancer screening: A review and commentary on the United States Preventive Services Draft Guidelines

Table 1 Findings from the DeeP-C cross-sectional study[5], comparing multitarget stool DNA with fecal immunological test using colonoscopy as the reference standard on all cases (n = 9989 subjects)

	Colonoscopy findings	mt-sDNA	FIT
	n detected	% detected	% detected
Sensitivity
Colorectal cancer (stages I-IV)	65	92.3%	73.8%
Early stage colorectal cancer (stage I and II)	50	94.0%	70.0%
AA	757	42.4%	23.8%
High grade dysplasia	39	69.2%	46.2%
Sessile serrated adenoma/polyp ≥ 1.0 cm	99	42.4%	5.1%
Specificity
Specificity (only CRC and AA excluded)	9167	86.6%	94.9%
Specificity, no adenomas, no biopsy done	4457	89.8%	96.4%
Age-adjusted (50-74 yr)[31]	4032	92.3%	97.0%

FIT: Fecal immunological test; AA: Advanced adenoma.