Expression of p-STAT3 and vascular endothelial growth factor in MNNG-induced precancerous lesions and gastric tumors in rats

Figure 4 Immunohistochemical score of p-signal transducer and activator of transcription 3 and vascular endothelial growth factor. A: The immunohistochemical score of p-signal transducer and activator of transcription 3 (STAT3) was significantly increased by N-methyl-N'-nitro-N-nitrosoguanidine during the progression from gastritis to gastric tumor. The p-STAT3 score in precancerous lesions and tumor samples was significantly higher than that in the normal sample; and the p-STATS score in dysplasia samples was significantly higher than that in gastritis and atrophic gastritis, which was comparable to that in tumor samples; B: Similar results were observed for the vascular endothelial growth factor score (^aP < 0.05 vs normal group; ^cP < 0.05 vs gastritis or atrophic gastritis).