Correlation of Helicobacter pylori and interleukin-8 mRNA expression in high risk gastric cancer population prediction

Table 5 Diagnostic values of each interleukin-8 mRNA expression cut-off point, 95%CI and gastric cancer diagnosis only gastric cancer cases (n = 86)

IL-8 level cut-off point	Sensitivity	Specificity	PPV	NPV	LHR+	LHR-	AuROC
1	96.8	8.7	41.7	80.0	1.06	0.37	0.53
	(92.8-100.0)	(2.4-15.0)	(30.6-52.7)	(71.1-88.9)	(0.95-1.18)	(0.04-3.16)	(0.48-0.58)
2	64.7	38.4	40.7	62.5	1.05	1.09	0.58
	(54.6-74.8)	(28.2-48.7)	(30.4-51.1)	(52.3-72.7)	(0.76-1.46)	(0.62-1.93)	(0.41-0.62)
3	41.9	69.6	48.2	64.0	1.38	1.20	0.56
	(30.9-53.0)	(59.3-79.8)	(37.0-59.3)	(53.3-74.7)	(0.75-2.52)	(0.84-1.71)	(0.45-0.67)
4	12.9	93.5	57.1	61.4	1.98	1.07	0.53
	(5.4-20.4)	(88.0-99.0)	(46.1-68.2)	(50.6-72.3)	(0.48-8.23)	(0.92-1.25)	(0.46-0.60)

P value of all AuROC = 0.832. PPV: Positive predictive value; NPV: Negative predictive value; LHR+: Positive likelihood ratio; LHR-: Negative likelihood ratio.