Correlation of Helicobacter pylori and interleukin-8 mRNA expression in high risk gastric cancer population prediction

Table 3 Logistic models and the area of the receiver operating characteristic curves comparing Helicobacter pylori pathology results and interleukin-8 mRNA expression with/without demographic characteristics

Variable	Model 1 Crude OR (95%CI)	Model 2 Crude OR (95%CI)	Model 3 Adjusted OR (95%CI)	Model 4 Adjusted OR (95%CI)	Model 5 Adjusted OR (95%CI)
Sex	-	-	2.99 (1.72-5.20)	3.31 (1.84-5.94)	3.29 (1.83-5.93)
Age group	-	-	3.79 (1.38-10.41)	4.25 (1.47-12.34)	4.19 (1.44-12.20)
H. pylori	0.86 (0.49-1.53)	-	0.94 (0.52-1.71)	-	0.91 (0.48-1.70)
IL-8 mRNA expression ≥ 2	-	5.44 (3.08-9.62)	-	6.05 (3.32-11.02)	6.07 (3.33-11.04)
AuROC	0.48 (0.42-0.54)a	0.71 (0.64-0.77)a	0.70 (0.63-0.76)	0.80 (0.75-0.86)b	0.81 (0.75-0.86)b

^aP value difference of AuROC = 0.532;

^bP value difference of AuROC < 0.001; H. pylori: Helicobacter pylori; AuROC: Area under the receiver operating characteristic curves.