Colon adenoma features and their impact on risk of future advanced adenomas and colorectal cancer

Table 4 Risk of concurrent and future advanced adenomas and colon cancer based on serrated polyps

Ref.	Sample size	Median follow-up, yr	Predictor	Primary outcome	Absolute risk	Risk [95%CI]
RCT
Holme et al[20]	100210	10.9	≥ 10 mm serrated polyp	Future CRC	3.4 vs 1.4 cases/1000 patient years	HR 3.3 [1.3-8.6]
Registry
Álvarez et al[17]	5059	None	Proximal l ≥ 10 mm	ACN	Not available	4.2 [1.7-10.2]
			Distal l ≥ 10 mm			2.6 [1.5-4.6]
			Proximal HP			1.6 [1.3-2.3]
Hiraoka et al[16]	10199	None	≥ 10 mm serrated polyps	ACN		4.0 [2.8-5.7]
				CRC	Not available	3.3 [2.2-5.0]
				Proximal CRC		4.8 [2.5-8.4]
Hazewinkel et al[19]	1426	None	Proximal SP	ACN	Not available	2.4 [1.6-3.8]
			Proximal HP			2.0 [1.1-3.4]
			Prox SSA/P			3.0 [1.5-6.2]
			≥ 10 SP			4.0 [1.9-8.6]
			≥ 10 mm HP			3.2 [1.1-9.1]
			≥ 10 mm SSA/P			5.0 [1.7-14.9]
Ng et al[18]	4989	None	SSA	ACN	Not available	4.5 [2.4-8.5]
			Proximal SP			2.2 [1.4-3.6]
			≥ 10 mmSP			59.3 [18.9-186.2]
			≥ 3 SP			4.9 [1.2-19.2]
			≥ 3 non-advanced adenomas			3.6 [2.6-5.0]
Schreiner et al[21]	3121	None	Proximal SP	AA	17.3 vs 10.0	1.9 [1.3-2.7]
			≥ 1 cm SP		27.3 vs 10.3	3.4 [1.7-6.7]
	1371	5.5	Proximal SP	Future
			without adenomas	AA	5.1 vs 2.7	3.1 [1.6-6.2]
			Proximal SP		7.9 vs 6.3	1.2 [0.5-3.8]
			with nonadvanced adenoma		28.9 vs 14.7	2.3 [1.0-5.0]
			Proximal SP
			with advanced adenoma

AA: Advanced adenomas; ACN: Advanced colonic neoplasia (includes advanced adenomas and cancer); HP: Hyperplastic polyp; HR: Hazard ratio; RCT: Randomized control trial; SP: Serrated polyp; SSA: Sessile serrated adenoma.