Colon adenoma features and their impact on risk of future advanced adenomas and colorectal cancer

Table 3 Articles summarizing the risk of colonic neoplasia based on the number of polyps seen at baseline colonoscopy

Ref.	Sample size	Median follow-up, yr	Predictor	Primary outcome	Absolute risk of outcome (%)	RR [95%CI]
RCT
Laiyemo et al[11]	1905	4	≥ 3 adenomas	ACN	10 (7-14) vs 6 (5-7)	1.5 [1.0-2.2]
Bonithon-Kopp et al[9]	552	3	≥ 3 adenomas	ACN	18.1 vs 5.0	2.7 [1.2-6.4]
Meta-analysis
Saini I et al[10]	5 studies	3	≥ 3 adenomas	ACN	5% risk difference (1-10)	2.5 [1.1-6.0]
Prospective
1Lieberman et al[12]	1193	5.5	1-2	ACN	4.6	1.9 [0.8-4.4]
			≥ 3		11.9	5.0 [2.1-12.0]
Chung et al[8]	3808	4.5	≥ 3 adenomas	ACN	Not available	3.1 [1.5-6.6]
Registry
Van Heijningen et al[13]	2990	2	1	AA	4	Ref
			2		7	1.6 [1.1-2.4]
			3		8	2.1 [1.3-3.4]
			4		12	2.0 [0.9-4.6]
			≥ 5		18	3.3 [1.7-6.6]
Ng et al[18]	4989	2		AA	Not available	Adjusted OR
			1			3.6 [2.6-5.0]
			2			7.1 [4.9-10.4]
			3			13.7 [0.9-4]

¹Relative risk compared to those with no neoplasia. ACN: Advanced colonic neoplasia (includes advanced adenomas and colorectal cancer); AA: Advanced adenomas; OR: Odds ratio; RCT: Randomized control trial.