Colon adenoma features and their impact on risk of future advanced adenomas and colorectal cancer

Table 2 Articles summarizing the risk of future colonic neoplasia based on the size of polyps seen at baseline colonoscopy

Ref.	Sample size	Median follow-up, yr	Predictor	Primary outcome	Absolute risk of outcome (%)	RR [95%CI]
RCT
Laiyemo et al[11]	1905	4	≥ 10 mm	ACN	9 (7-11) vs 5 (4-6)	0.9 [0.6-1.4]
Bonithon-Kopp et al[9]	552	3	≥ 10 mm	ACN	7.1 vs 7.8	1.1 [0.5-2.1]
Pooled analysis
Martínez et al[14]	8 studies	3.9	< 5 mm	ACN	8.7 (7.7-9.7)	Ref
	9167		10-19 mm		15.9 (14.5-17.4)	2.3 [1.8-2.8]
			≥ 20 mm		19.3 (16.4-22.3)	3.0 [2.2-4.0]
Meta-analysis
Saini I et al[10]	5 studies	3	≥ 10 mm	ACN	2% risk difference (-2 to 6)	1.4 [0.9-2.3]
Prospective
Bertario et al[15]	1086	10.5	≥ 20 mm	Any adenoma	Not available	1.5 [1.1-2.1]
				CRC	SIR	Not available
			Baseline		0.52 [0.3-0.9]
			< 10 mm		0.33 [0.1-0.9]
			≥ 10 mm		0.82 [0.3-1.8]
Lieberman et al[12]	1193	5.5	≥ 10 mm	ACN	15.5 vs 2.4	6.4 [2.7-14.9]
Chung et al[8]	3808	4.5	≥ 10 mm	ACN	Not available	3.0 [1.8-5.1]
Registry
Van Heijningen et al[13]	2990	2	≥ 10 mm	AA	8 vs 4	1.7 [1.2-2.3]

ACN: Advanced colonic neoplasia (includes advanced adenomas and colorectal cancer); AA: Advanced adenomas; CRC: Colorectal cancer; RCT: Randomized control trial; SIR: Standard incidence ratio.