Current noninvasive tests for colorectal cancer screening: An overview of colorectal cancer screening tests

Table 1 The sensitivity and specificity of qualitative and quantitative fecal immunochemical test

Qualitative FIT					Quantitative FIT
Ref.	Total cases	CRCcases	Sensitivity	Specificity	Ref.	Total cases	CRC cases	Sensitivity	Specificity
Allison et al[12], 1996	7493	35	0.69	0.94	Sohn et al[22], 2005	3794	12	0.25	0.99
Allison et al[15], 2007	5356	14	0.86	0.97	Levi et al[23], 2011	1204	6	1.00	0.88
Cheng et al[16], 2002	7411	16	0.88	0.91	Levi et al[24], 2007	80	3	0.67	0.83
Nakama et al[17], 1999	4611	18	0.56	0.97	Morikawa et al[25], 2005	21805	79	0.66	0.95
Nakama et al[18], 1996	3365	12	0.83	0.96	Launoy et al[26], 2005	7421	28	0.86	0.94
Parra-Blanco et al[19], 2010	1756	14	1.00	0.93	Itoh et al[27], 1996	27860	89	0.87	0.95
Chiu et al[20], 2013	8822	13	0.85	0.92	Nakazato et al[28], 2006	3090	19	0.53	0.87
Chiang et al[21], 2011	2796	28	0.96	0.87	Park et al[29], 2010	770	13	0.77	0.94
					de Wijkerslooth et al[30], 2012	1256	8	0.75	0.95
					Brenner et al[31], 2013	2235	15	0.73	0.96
					Brenner et al[31], 2013	2235	15	0.60	0.95
Overall (pooled data)	41610	150	0.82	0.93		71750	287	0.73	0.95

CRC: Colorectal cancer; FIT: Fecal immunochemical test.