Impact of RAS and BRAF mutations on carcinoembryonic antigen production and pattern of colorectal metastases

Table 4 BRAF status and pattern of colon cancer metastases

Ref.	n (%BRAF)	End point	%BRAF MT vs %BRAF WT	P
Tran et al[8]	524 (11%)	Rate of peritoneal metastases	46% vs 24%	0.001
		Rate of distant lymph node metastases	53% vs 38%	0.008
		Rate of lung metastases	35% vs 49%	0.049
Yaeger et al[9]	515 (18%)	Peritoneal involvement at presentation	26% vs 14%	< 0.01
Kawazoe et al[12]	264 (5%)	Peritoneal metastasis	50% vs 18%	0.009

n: Total number of patients; %BRAF: %patients with BRAF mutation; MT: Mutant; WT: Wild type.