Role of microRNA-7 in digestive system malignancy

Table 2 Function of microRNA-7 by targeting diverse genes

Cells	Function of miR-7	Target	Ref.
CCA	Reduces migration, invasion and metastasis	LAT1	[41]
CRC	Inhibits proliferation, invasion and metastasis, and induces G1 arrest	PAX6	[21]
CRC	Inhibits proliferation and induces apoptosis	XRCC2	[22]
CRC	Suppresses proliferation, induces G1 arrest, and induces apoptosis	YY1	[37]
GC	Suppresses invasion and metastasis	IGF1R	[18]
GC	Inhibits proliferation, invasion and metastasis	EGFR	[19]
HCC	Decreases invasion and migration	PIK3CD/mTOR/p70S6K	[28]
HCC	Suppresses colony formation and induces cell cycle arrest	CUL5	[23]

CCA: Cholangiocarcinoma; CRC: Colorectal cancer; GC: Gastric cancer; HCC: Hepatocellular carcinoma; miR-7: MicroRNA; XRCC2: X-ray repair complementing defective repair in Chinese hamster cells 2; IGF1R: Insulin-like growth factor 1 receptor; EGFR: Epidermal growth factor receptor; mTOR: Mammalian target of rapamycin; CUL5: Cullin 5.