Hereditary diffuse gastric cancer: What the clinician should know

Table 1 Clinical criteria for CDH1 genetic testing (adapted from Fitzgerald et al[11])

≥ 2 diffuse GC cases in 1st or 2nd degree relatives with one < 50 yr of age

≥ 3 diffuse GC cases in 1st or 2nd degree relatives independent of age

Diffuse GC < 40 yr of age, without a family history

Personal or family history of diffuse GC and lobular breast cancer with one < 50 yr of age

GC: Gastric cancer.