Anti program death-1/anti program death-ligand 1 in digestive cancers

Figure 2 The program death-1 and program death-ligand 1 axis blockade. A: The PD-1 and PD-L1 interactions: PD1 has two ligands called PD-L1 and PD-L2. PD-L1 can interact either with PD-1 or B7.1; B: Anti PD-1 monoclonal antibody blockade prevents PD-L1 and PD-L2 ligation to PD-1 but not the B7.1 and PD-L1 interaction; C: Anti PD-L1 monoclonal antibody blockade prevents PD-1 and B7.1 ligation to PD-L1 but not the PD-1 and PD-L2 interaction. PD-1: Program death-1; PD-L1: Program death-ligand 1; PD-L2: Program death-ligand 2.