Epigenetic reduction of DNA repair in progression to gastrointestinal cancer

Table 3 Epigenetic deficiency of DNA repair genes in gastrointestinal cancers and field defects

Cancer	Gene	Frequency in cancer	Frequency in adjacentfield defect
Colorectal[17]	MGMT	46%	34%
Colorectal[19]	MGMT	47%	11%
Colorectal[60]	MGMT with MSI	70%	60%
Colorectal[19]	MSH2	13%	5%
Colorectal[61]	MBD4	Frequent	Frequent
Colorectal[62]	ERCC1	100%	40%
Colorectal[62]	PMS2	88%	50%
Colorectal[62]	XPF	55%	40%
Colorectal[63]	WRN	29%	13%
Stomach[64]	MGMT	88%	78%
Stomach[65]	MLH1	73%	20%
Esophagus[66]	MLH1	77%-100%	23%-79%

MSI: Microsatellite instability.