Role of histone deacetylases in pancreas: Implications for pathogenesis and therapy

Figure 2 Histone deacetylases in acute and chronic pancreatitis. HDACs induce key pro-inflammatory mediators in AP and CP leading to destruction of pancreatic tissue with necrosis in case of AP and fibrosis/atrophy in case of CP. Inhibition of HDACs by HDACis was shown to significantly antagonist these effects in vitro and in vivo. HDAC: Histone deacetylases; HDACis: Histone deacetylases inhibitors; NG: Neutrophil granulocyte; IL: Interleukin; TNF: Tumor necrosis factor; PDGF: Platelet-derived growth factor; TGF: Transforming growth factor; SAHA: Suberoylanilide hydroxamic acid; SB: Sodium butyrate; TSA: Trichostatin A.