Role of histone deacetylases in pancreas: Implications for pathogenesis and therapy

Figure 1 Histone deacetylases and histopathological correlates in the transition from normal to acute/chronic pancreatitis and pancreatic cancer. The trend to increased expression (based on pharmacological inhibition studies) of HDACs from normal to pancreatic cancer tissue is shown in the lower part of the figure. In pancreatic cancer, up-regulation of HDAC-1,-2,-3,-7,-8 could be demonstrated - see text for details - probably offering approaches for personalized therapies based on specific HDAC inhibition. HDAC: Histone deacetylases; AP: Acute pancreatitis; CP: Chronic pancreatitis.