Management of asymptomatic primary tumours in stage IV colorectal cancer: Review of outcomes

Table 5 Independent prognostic factors influencing overall survival on multivariate analysis, with hazard ratios or odds ratios for death

Ref.	Age	Sex	ECOG PS≥2	Tumour location: Right colon	Tumour differentiation	T stage	N stage	M1b(vs M1a)	Presence of liver mets	Extent of hepatic involvement	Pre treatment CEA	Chemotherapy regime: Non use of Oxaliplatin/Irinotecan
Cetin et al[22] (2013)	a	a									a
Yun et al[18] (2014)1	a	a		a	a	a	a	HR 1.39	HR 1.31		a
Galizia et al[25] (2008)	a	a	HR 3.18	a	a	a	a			HR 5.792	a
Matsuda et al[17] (2013)	a	a		a	a		a		a		a	HR 2.57
Bajwa et al[27] (2009)	a		a	OR 2.61	a					a	a
Maeda et al[28] (2013)	a	a	OR 2.73	a	a	a	a	OR 1.66			a
Seo et al[20] (2010)	a	a	a	a	HR 2.824			a		HR 2.415	a	HR 1.896
Michel et al[21] (2004)										a

a: Factor investigated by authors and found to be non-significant on multivariate analysis;

¹Unmatched cohort;

²> 50% hepatic replacement (vs < 50% hepatic replacement);

³ECOG PS ≥ 1 (vs 0);

⁴High grade (vs low grade);

⁵> 5 liver metastases (vs < 5);

⁶Oxaliplatin use only. ECOG: Eastern Co-operative.