Management of asymptomatic primary tumours in stage IV colorectal cancer: Review of outcomes

Table 3 Primary tumour related complications in patients undergoing primary chemotherapy

Ref.	% of patients requiring intervention for primary tumour related complications	Most common complication	Comment
Yun et al[18] (2014)	3%	Obstruction > perforation	Mean onset of complications = 8 mo
Cetin et al[22] (2013)	4%	Obstruction > rectovesical fistula	-
Muratore et al[46] (2007)	6%	Obstruction > haemorrhage	-
Clements et al[45] (2009)	8%	All obstruction	-
Scoggins et al[44] (1999)	9%	All obstruction	Mean onset of complications = 3 mo
Poultsides et al[24] (2009)	11%	Obstruction > perforation > pain	-
Seo et al[20] (2010)	14%	Obstruction > bleeding	-
Benoist et al[26] (2005)	15%	All obstruction	-
McCahill et al[16] (2012)	16%	Obstruction > perforation, pain	Majority onset of complications < 12 mo
Michel et al[21] (2004)	22%	All obstruction	Mean onset of complications = 4 mo
Yun et al[23] (2014)	22%	Obstruction > perforation	Mean onset of complications = 7 mo
Matsumoto et al[19] (2014)	26%	Majority obstruction	-
Ruo et al[43] (2003)	29%	All obstruction	Majority onset of complications < 6 mo
Galizia et al[25] (2008)	30%	Obstruction> perforation > haemorrhage	Mean onset of complication = 11 mo
Sarela et al[47] (2001)	33%	Obstruction > pain > tenesmus	Mean onset of complication = 9 mo
Bajwa et al[27] (2009)	40%	Obstruction > bleeding