Management of asymptomatic primary tumours in stage IV colorectal cancer: Review of outcomes

Table 2 Overall survival

Ref.	Unadjusted median OS (mo)			Adjusted survival outcomes: Is PTR superior?
	PTR	PC	P value
Galizia et al[25] (2008)	15	12	P = 0.03	Yes (HR for death PC = 3.91, 95%CI: 2.83-4.99, P = 0.01)
Ahmed et al[42] (2014) Subgroup	15	8	P < 0.01	Yes (analysis not shown)
Ruo et al[43] (2003)	16	9	P < 0.001	No adjusted survival data
Yun et al[18] (2014) Matched cohort	17	14	P = NS	No (HR for death PC = 1.16, 95%CI: 0.89-1.52, P = 0.27)
Matsumoto et al[19] (2014)	24	23	P = NS	No (HR for death PTR = 0.72, 95%CI: 0.42-1.25, P = NS)
Seo et al[20] (2010)	22	14	P = NS	No (HR for death PC = 1.73, 95%CI: 0.94-3.16, P = 0.07)
Benoist et al[26] (2005) Matched cohort	23	22	P = NS	No (HR not reported, P = 0.753)
Cetin et al[22] (2013)	23	17	P = NS	No adjusted survival data
Michel et al[21] (2004)	21	14	P = NS	No adjusted survival data
Scoggins et al[44] (1999)	14	17	P = NS	No adjusted survival data
Boselli et al[15] (2013)	4	5	P = NS	No (HR for death PTR = 2.1, 95%CI: 1.06-4.5, P = 0.03)

NS: Not significant (P > 0.05); PTR: Primary tumour resection; PC: Primary chemotherapy; HR: Hazard ratio.