Neo-adjuvant chemo(radio)therapy in gastric cancer: Current status and future perspectives

Table 4 Currently recruiting trials for pre and peri-operative chemo(radio)therapy

Country	Title	Phase	Study arms	Trial registration
United Kingdom[51]	Chemotherapy with or without bevacizumab or lapatinib to Treat Operable Oesophagogastric Cancer (ST03)	II/III	ECX + bevacizumab vs ECX vs ECX + lapatinib	NCT00450203
United Kingdom[52]	A study of bevacizumab in combination with capecitabine and cisplatin as first-line therapy in Patients With Advanced Gastric Cancer (AVAGAST)	III	Bevacizumab + ECX vs ECX	NCT00548548
Multicenter study (24 countries)[53]	ToGA study - A study of herceptin (trastuzumab) in combination with chemotherapy compared with chemotherapy alone in patients with HER2-positive Advanced Gastric Cancer	III	Trastuzumab + fluorouracil/capecitabine + cisplatin vs fluorouracil/capecitabine + cisplatin	NCT01041404
Australia and New Zealand	Trial of Preoperative Therapy for Gastric and Esophagogastric Junction Adenocarcinoma (TOPGEAR)	II/III	Epirubicin + cisplatin + 5-fluorouracil + 45 Gy vs Epirubicin + cisplatin + 5-fluorouracil	NCT01924819
Netherlands[54]	Randomized phase III trial of adjuvant chemotherapy or Chemoradiotherapy in Resectable Gastric Cancer (CRITICS)	III	ECC + surgery + ECC vs ECC + surgery + 45 Gy + capecitabine + cisplatin	NCT00407186
China	Peri-operative chemotherapy with ECX or XP in the treatment of advanced gastric cancer	III	Epirubicin + cisplatin + capecitabine vs capecitabine + cisplatin	NCT01558947
Korea	DOS regimen as neoadjuvant chemotherapy in advanced gastric cancer (PRODIGY)	III	Docetaxel + oxaliplatin + tegafur vs surgery only	NCT01515748
China	Peri-operative chemotherapy with ECX (epirubicin + cisplatin + capecitabine) or XP (capecitabine + cisplatin) in the treatment of advanced gastric cancer: A randomized, multicenter, parallel controlle	III	Epirubicin + cisplatin + capecitabine vs capecitabine + cisplatin	ChiCTR-TRC-11001319
Ireland	MAGIC vs CROSS Upper GI. ICORG 10-14	III	MAGIC regimen vs CROSS protocol	NCT01726452

AVAGAST: The Avastin in gastric cancer; ECX: Epirubicin, cisplatin and xeloda; TOPGEAR: Trial of preoperative therapy for gastric and esophagogastric junction adenoca rcinoma; CRITICS: Chemoradiotherapy after induction. chemotherapy in cancer of the stomach; XP: Xeloda and cisplatin; DOS: Docetaxel, oxaliplastin and S1; MAGIC: Medical research council adjuvant gastric infusional chemotherapy; CROSS: Chemoradiotherapy for oesophageal cancer followed by surgery study; ICORG: Ireland cooperative oncology research group.