Clinical significance of MET in gastric cancer

doi:10.4251/wjgo.v7.i11.317

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World Journal of Gastrointestinal Oncology

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World J Gastrointest Oncol. Nov 15, 2015; 7(11): 317-327
Published online Nov 15, 2015. doi: 10.4251/wjgo.v7.i11.317

Table 4 Development of MET-targeting agents for gastric cancer

Type	Agent	Other targets	Phase	Line	Combined therapy	Results or status	Ref.
MET selective	Tivantinib (ARQ197)	None	II	2^nd/3^rd	None	No CR/PR	[72]
non-ATP competitive TKI	Tivantinib (ARQ197)	None	II	2^nd/3^rd	None	Median PFS 1.4 mo	[72]
MET-selective	AMG 337	None	II	Any	None	Ongoing	[74]
ATP-competitive TKI			I	2^nd/3^rd	None	1 CR and 4 PR in 10 patients with MET -amplified tumor	[73]
Multitargeted	Foretinib	VEGFR2, RON, AXL, TIE2	II	1^st (95%)	Docetaxel, Cisplatin	No CR/PR	[75]
ATP-competitive TKI	(GSK1363089)	VEGFR2, RON, AXL, TIE2	II	1^st (95%)	Docetaxel, Cisplatin	Median OS 7.4	[75]
	Crizotinib	ALK	I			Tumor shrinkage in 2 patients with PFS 3.5 and 3.7 mo	[39]
	(PF-2341066)	ALK	I			Tumor shrinkage in 2 patients with PFS 3.5 and 3.7 mo	[39]
MET mAb	Onartuzumab (MetMab )	None	III	1^st	mFOLFOX	Ongoing	[77]
HGF mAb	Rilotumumab	None	III	1^st	ECX	Suspended	[79]
	(AMG 102)	None	III	1^st	CX	Suspended	[80]
		None	II	1^st	ECX	Median PFS 4.2 mo	[78]
		None	II	1^st	ECX	Median OS 5.6 mo	[78]

ATP: Adenosine triphosphate; TKI: Tyrosine kinase inhibitor; mAb: Monoclonal antibody; VEGFR: Vascular endothelial growth factor receptor; ALK: Anaplastic lymphoma kinase; TIE: Tunica internal endothelial cell kinase; CR: Complete response; PR: Partial response; RFS: Relapse-free survival; OS: Overall survival; FOLFOX: Folinic acid + fluorouracil + oxaliplatin; ECX: Epirubicin + oxaliplatin + capecitabine; CX: Oxaliplatin + capecitabine.

Citation: Inokuchi M, Otsuki S, Fujimori Y, Sato Y, Nakagawa M, Kojima K. Clinical significance of MET in gastric cancer. World J Gastrointest Oncol 2015; 7(11): 317-327
URL: https://www.wjgnet.com/1948-5204/full/v7/i11/317.htm
DOI: https://dx.doi.org/10.4251/wjgo.v7.i11.317