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©The Author(s) 2015.
World J Gastrointest Oncol. Oct 15, 2015; 7(10): 178-183
Published online Oct 15, 2015. doi: 10.4251/wjgo.v7.i10.178
Published online Oct 15, 2015. doi: 10.4251/wjgo.v7.i10.178
Table 1 Fecal DNA markers for advanced adenoma and colorectal cancer n (%)
| Ref. | Marker | Sensitivity | Specificity | |
| CRC | Adenoma > 1 cm | |||
| [12] | Meth BMP3, hDNA, KRAS, APC | 67 (91) | 21 (78) | 85 (85) |
| [13] | APC, KRAS, p53, long DNA | 3 (25) | 47 (8) | 2246 (96) |
| [14] | APC, KRAS, p53, long DNA | 16 (52) | 84 (12) | 1344 (94) |
| [15] | β-actin, KRAS, meth BMP3 and NDRG4, fecal hemoglobin | 91 (98) | 48 (57) | 139 (90) |
| [16] | KRAS, a actina Meth NDRG4, BMP3, vimentin, TFPI2 | 214 (85) | 72 (54) | 264 (90) |
| [17] | KRAS, NDRG4, BMP3, β-actin, fecal hemoglobin | 60 (92) | 321 (42) | 4457 (90) |
| [20] | Meth vimentin | 9 (41) | 9 (45) | 63 (95) |
| [21] | Meth SFRP2 | 60 (87) | 21 (62) | 28 (93) |
| [22] | Meth TFPI2, long DNA | 52 (87) | 4 (44) | 25 (83) |
| [23] | Meth SFRP2, HPPI, MGMT | 50 (96) | 15 (71) | 23 (96) |
| [24] | Meth APC, ATM, hMLH1, sFRP2, HLTF, MGMT, and GSTP1 | 15 (75) | 17 (68) | 27 (90) |
| [25] | Meth vimentin, long DNA | 68 (83) | 6 (86) | 298 (82) |
| [26] | Meth RASSF2 or SFRP2 | 63 (75) | 25 (44) | 101 (89) |
| [27] | Meth vimentin, MLH1, MGMT | 45 (75) | 31 (60) | 32 (87) |
| [28] | Meth RARB2, p16INK4a, MGMT, APC | 16 (62) | 8 (40) | 20 (100) |
- Citation: Dhaliwal A, Vlachostergios PJ, Oikonomou KG, Moshenyat Y. Fecal DNA testing for colorectal cancer screening: Molecular targets and perspectives. World J Gastrointest Oncol 2015; 7(10): 178-183
- URL: https://www.wjgnet.com/1948-5204/full/v7/i10/178.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v7.i10.178