Genotypic characteristics of resistant tumors to pre-operative ionizing radiation in rectal cancer

Figure 9 Orthotopic model for the study of rectal cancer. This model has the following characteristics: (1) cecal transplantation of tumors with a known response to ionizing radiation; (2) attachment of the cecum to the lateral abdominal wall with a permanent suture for the administration of ionizing radiation; and (3) transfection of cells with luciferase before tumor implantation for the assessment of the chemoradiotherapeutic interventions over time by bioluminescence imaging before the end of the study. This technique allows targeted delivery of ionizing radiation in an intraperitoneal tumor.