Genotypic characteristics of resistant tumors to pre-operative ionizing radiation in rectal cancer

Table 2 Non-homologous end-joining inhibitors

Inhibitor	Mechanism/comments
A12B4C3	PNKP inhibitor, sensitizes cells to camptothecin
BTW3	A small peptide DNA-PK inhibitor, proposed to compete for DNA-PKcs autophosphorylation
KU0060648	DNA-PK and P13K inhibitor
NU7441/KU57788	DNA-PK inhibitor, competitive with ATP
ScFv 18-2	An antibody-derived DNA-PK inhibitor that can bind to an epitope unique to DNA-PKcs
ZSTK474	DNA-PK and P13K inhibitor, competitive with ATP; in phase 1 clinical trials (NCT01280487 and NCT01682473)
CC-115	Dual inhibitor of DNA-PKcs and mTOR, in phase 1 clinical trials
CC-122	DNA-PK inhibitor, in phase 1 clinical trials

Reprinted with permission from Elsevier[149]. P13K: Phosphatidyl inositol 3 kinase.