Primary tumor resection in colorectal cancer with unresectable synchronous metastases: A review

Table 1 Median survival (mo) in patients with unresectable metastatic colorectal cancer, according to whether primary tumor resection was performed or not

Ref.	Study period	Resection/No resection	No.of patients	OS(mo)	P value
Scoggins et al[82]	1985-1997	Resection	66	14.5	0.59
		No resection	23	16.6
Tebbutt et al[34]	1990-1999	Resection	280	14	0.08
		No resection	82	8.2
Ruo et al[44]	1996-1999	Resection	127	16	< 0.001
		No resection	103	9
Michel et al[90]	1996-1999	Resection	31	21	0.718
		No resection	23	14
Law et al[35]	1996-1999	Resection	150	7	< 0.001
		No resection	30	3
Benoist et al[79]	1997-2002	Resection	32	23	NS
		No resection	27	22
Stelzner et al[45]	1995-2001	Resection	128	11.4	< 0.0001
		No resection	58	4.6
Konyalian et al[36]	1991-2002	Resection	62	13	< 0.0001
		No resection	47	5
Costi et al[91]	1994-2003	Resection	83	9	< 0.001
		No resection	47	4
Yun et al[37]	1994-2004	Resection	283	15.3	< 0.001
		No resection	93	5.3
Kaufman et al[92]	1998-2003	Resection	115	22	< 0.0001
		No resection	69	3
Galizia et al[38]	1995-2005	Resection	42	15.2	0.03
		No resection	23	12.3
Evans et al[70]	1999-2006	Resection	45	11	< 0.0001
		No resection	57	2
Bajwa et al[39]	1999-2005	Resection	32	14	0.005
		No resection	35	6
Mik et al[40]	1996-2000	Resection	52	21	NS
		No resection	82	14
Frago et al[93]	2004-2008	Resection	12	23.7	0.008
		No resection	43	4.4
Aslam et al[41]	1998-2007	Resection	366	14.5	< 0.005
		No resection	281	5.83
Chan et al[11]	2000-2002	Resection	286	14	< 0.001
		No resection	125	6
Seo et al[94]	2001-2008	Resection	114	22	0.076
		No resection	83	14
Karoui et al[33]	1998-2007	Resection	128	30.7	0.031
		No resection	85	21.9
Ferrand et al[22]	1997-2001	Resection	156	16.3	< 0.0001
		No resection	60	9.5

OS: Overall survival.