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World J Gastrointest Oncol. Mar 15, 2014; 6(3): 55-66
Published online Mar 15, 2014. doi: 10.4251/wjgo.v6.i3.55
Published online Mar 15, 2014. doi: 10.4251/wjgo.v6.i3.55
Figure 5 Lipid peroxidation, smoking and the activation of benzo[a]pyrene.
Lipid peroxidation and cytochrome P450 2S1 (CYP2S1) can activate benzo[a]pyrene (BaP) to the potent mutagen, benzo[a]pyrene-r-7,t-8-dihydrodiol-t-9,10-epoxide (BaP-diol-t-epoxide). A high expression of CYP2S1 is associated with colorectal cancer and a poor prognosis (see text).
- Citation: Stone WL, Krishnan K, Campbell SE, Palau VE. The role of antioxidants and pro-oxidants in colon cancer. World J Gastrointest Oncol 2014; 6(3): 55-66
- URL: https://www.wjgnet.com/1948-5204/full/v6/i3/55.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v6.i3.55