Novel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancer

Figure 1 The microarray signature profile of circulating microRNA in pancreatic cancer patients and healthy controls. A: The unsupervised hierarchical clustering of 290 miRNAs that are differentially expressed among pancreatic cancer patients (n = 8) and healthy controls (n = 11). The dendrogram on top indicates the hierarchical clustering relationship between pancreatic cancer patients (in red) and healthy controls (in blue); B: Heat map depicting the subset of 42 miRNAs chosen for confirmation RT-qPCR study, arranged as indicated. Heat map color scale represents fold increase (red) or decrease (green) from baseline. MiRNA: MicroRNA.