Antidepressant fluoxetine and its potential against colon tumors

Figure 4 Schematic illustration shows fluoxetine anti-angiogenic potential in colon preneoplastic tissue. This means that by reducing proliferation of subepithelial cells, blocking their cell-cycle, fluoxetine would reduce microvessel density. This anti-angiogenic potential was observed in a direct relationship with reduced differentiation-related angiogenesis of subepithelial stem cells. This suggests that fluoxetine would reduce the differentiation of CD133 positive cells into a CD34 phenotype, which would also not differentiate in endothelial cells, as CD31. This sequence of events would mainly be associated with the control of fluoxetine treatment on nuclear factor kappa-B signaling, as reducing proliferation and preneoplastic angiogenesis. PCNA: Proliferating cell nuclear antigen.