Novel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancer

Table 2 The 42 microRNAs for confirmation study

MiRNA	Fold change	FDR	Ref
Up-regulated in Pancreatic Cancer
MiR-3184	4.5	0.005
MiR-642b	3.3	0.028
MiR-1909	3.0	0.030
MiR-3154	3.5	0.064
MiR-711	3.1	0.064
MiR-3125	5.2	0.069
MiR-4253	2.8	0.082
MiR-762	2.4	0.082
MiR-885-5p	3.0	0.103
MiR-3188	2.4	0.154
MiR-194	2.1	0.154	[19]
MiR-193b	2.4	0.155
MiR-22	1.4	0.706	[19,20]
Up-regulated in Healthy Controls
MiR-486-5p	3.0	0.064
MiR-18b	2.9	0.064
MiR-1288	2.6	0.064
MiR-486-3p	2.3	0.082
MiR-18a	2.7	0.082	[19,25]
MiR-7	2.5	0.091	[19]
MiR-26b	3.9	0.112	[19]
MiR-646	2.5	0.131
MiR-1295	2.4	0.131
MiR-301a	2.4	0.131	[18]
MiR-106b	2.3	0.151	[19]
Let-7i	4.0	0.154	[20]
MiR-16	3.7	0.154	[17,19]
MiR-20b	2.9	0.154
MiR-93	2.6	0.154	[19]
MiR-106a	2.6	0.154	[17,19]
MiR-17	2.5	0.154
MiR-19b	2.5	0.154	[19]
MiR-1468	2.2	0.154
MiR-29b	2.1	0.171	[20]
MiR-15b	2.3	0.172	[19]
MiR-186	1.8	0.196	[19]
MiR-10b	1.9	0.250	[19]
MiR-143	2.3	0.323	[19,20]
MiR-181a	1.7	0.361	[14,19]
MiR-222	1.6	0.546	[14,17-19]
MiR-221	1.6	0.546	[14,18,19]
MiR-210	1.2	0.813	[17,19]
MiR-21	1.4	0.866	[14,18,19]

The 42 final target list based on the 290 miRNAs identified by miRNA microarray. The fold change shown is calculated as the ratio of pancreatic cancers over healthy controls (under “Up-regulated in Pancreatic Cancer”) or healthy controls over pancreatic cancers (under “Up-regulated in Healthy Controls”). MiRNA: MicroRNA; FDR: False discovery rate.