Pneumo-CT assessing response to neoadjuvant therapy in esophageal cancer: Imaging-pathological correlation

Figure 8 Epidermoid carcinoma of the thoracic esophagus [CME #5]. Dworak grade 4, absence of tumor cells. A: Axial pre-neoadjuvant therapy image. Both wall thickness and density are measured; B: Axial post- neoadjuvant therapy image reveals a clear decrease of the wall thickening and density; C: Axial pre- neoadjuvant therapy image, the arrow is pointing to adenopathy; D: Axial post-neoadjuvancy image reveals disappearance of adenopathy; E: Coronal multiplanar reconstructions (MPR) pre-neoadjuvant therapy reconstruction. The circle shows the long axis of the tumor; F: Coronal MPR reconstruction post- neoadjuvant therapy. The neoplasm is not longer detected; G: Surgical specimen of total esophagectomy and upper polar gastrectomy. Open piece, is recognized at the level of the gastro-esophageal junction an area of white-depressed with elevated edges; H: Squamous epithelium with acanthosis, conserved cell polarity. Fibrohialinosis in lamina propria and submucosa with lymphocytic infiltrate. Absence of atypical cells. At the level of the gastroesophageal junction shows a sector with intestinal metaplasia in the stomach side, negative for dysplasia.