Surgery for colorectal liver metastases: The evolution of determining prognosis

Table 1 Studies of prognostic clinicopathological factors

Study	Primary stage	CEA level	Size of major metastasis	Number liver metastases	Disease free interval	Extrahepatic disease	Surgical margins
Scheele et al[11]	P	NA	P	NP	P	P	P
Nordlinger et al[10]	P	P	P	P	P	NA	P
Fong et al[9]	P	P	P	P	P	P	P
Mann et al[12]	P	P	P	NP	NP	NA	NA
Rees et al[15]	P	P	P	P	NA	P	P
John et al[21]	NP	P	NP	NP	NA	NP	P
Doci et al[27]	P	NP	NP	NP	NP	NA	NA
Hughes et al[34]	P	P	P	P	P	NA	NA
Gayowski et al[37]	P	NA	NP	P	NP	P	P

CEA: Carcinoembryonic antigen; P: Prognostic; NP: Non prognostic; NA: Non available.