Leukocyte DNA methylation and colorectal cancer among male smokers

Table 2 Methylation of CpG sites associated with colorectal cancer development (P value < 0.01 before multiple testing correction)¹

Marker name	2nd tertile vs 1st tertile			3rd tertile vs 1st tertile			P2
	OR	L95	U95	OR	L95	U95
DSP	1.09876	0.95772	1.26057	1.26539	1.11734	1.43306	0.000599826
MLH3	1.04349	0.90638	1.20134	1.26606	1.0994	1.45798	0.000731318
FLT4	1.25952	1.10631	1.43394	1.14513	0.98989	1.32473	0.00096231
INSR	1.16236	1.01962	1.32509	1.24011	1.09317	1.40681	0.001490452
GLA	1.37049	1.15665	1.62388	1.44612	1.19452	1.75072	0.001636963
PTCH2	1.18022	1.03475	1.34615	1.26374	1.11417	1.43339	0.001637435
GSTM2	1.24321	1.09656	1.40947	1.17084	1.02674	1.33516	0.001994473
HCK	1.18573	1.04409	1.34659	1.19691	1.03199	1.38819	0.002287131
PLAGL1	0.91619	0.80363	1.04451	0.87645	0.75745	1.01414	0.002326078
PARP1	1.07016	0.95	1.20553	0.86663	0.75535	0.9943	0.003005978
COL18A1	1.23987	1.08901	1.41162	1.20014	1.05351	1.36719	0.003163099
KCNK4	1.19498	1.05273	1.35645	1.15065	1.00785	1.31368	0.003250103
GJB2	1.16605	1.02831	1.32224	1.02785	0.89877	1.17547	0.003317356
SEMA3F	1.16703	1.01753	1.33848	1.16456	1.01456	1.33673	0.00380004
HBII	0.89709	0.79121	1.01713	0.86969	0.7624	0.99207	0.004064919
SEMA3C	1.08773	0.96383	1.22756	0.87597	0.76919	0.99757	0.004352617
MME_	1.18426	1.04194	1.34601	1.17187	1.02959	1.3338	0.005258668
WNT1_	1.18575	1.02807	1.36761	1.07102	0.91035	1.26004	0.005648004
SGCE	1.0712	0.93671	1.22501	1.22832	1.08144	1.39516	0.00629186
PDE1B_	1.24257	1.09182	1.41413	1.21384	1.04623	1.40831	0.008629968
HIC1	1.16348	1.01124	1.33864	1.22483	1.06765	1.40515	0.008997589
PODXL	1.16034	1.02143	1.31815	1.12456	0.98675	1.2816	0.009182736
IL18BP	1.17737	1.0254	1.35188	1.07299	0.91441	1.25908	0.009206805
DKC1	1.05822	0.92046	1.2166	1.22886	1.05463	1.43187	0.009315729
B3GALT5	0.95137	0.83621	1.08239	1.20365	1.05804	1.3693	0.009772808
SNRPN	0.85441	0.7514	0.97155	0.98115	0.86779	1.1093	0.00995797

¹The markers detected here could be markers indicating susceptibility;

²P from logistic regression model (all cases were included).