Serum M2-pyruvate kinase: A promising non-invasive biomarker for colorectal cancer mass screening

Table 3 Diagnostic sensitivity and specificity in percentage at 95% confidence interval of serum M2-pyruvate kinase using various cut-off value settings for different colorectal lesions compared with 158 normal people in colorectal cancer mass screening in Hangzhou, 2006-2008 (95% CI)

M2-PK (U/mL)	Colorectal cancer		Advanced adenoma		Adenoma		Non-adenomatous polyp
	Sensitivity	Specificity	Sensitivity	Specificity	Sensitivity	Specificity	Sensitivity	Specificity
2.00	100.00 (100.00-100.00)	40.51 (32.85-48.16)	95.12 (88.53-100.00)	40.51 (32.85-48.16)	82.48 (76.12-88.85)	40.51 (32.85-48.16)	82.98 (72.23-93.72)	40.51 (32.85-48.16)
2.50	94.62 (90.04-99.21)	55.06 (47.31-62.82)	85.37 (74.55-96.18)	55.06 (47.31-62.82)	71.53 (63.98-79.09)	55.06 (47.31-62.82)	76.60 (64.49-88.70)	55.06 (47.31-62.82)
3.00	91.40 (85.70-97.10)	65.19 (57.76-72.62)	75.61 (62.46-88.75)	65.19 (57.76-72.62)	61.31 (53.16-69.47)	65.19 (57.76-72.62)	65.96 (52.41-79.50)	65.18 (57.76-72.62)
3.50	87.10 (80.28-93.91)	68.99 (61.78-76.20)	73.17 (59.61-86.73)	68.99 (61.78-76.20)	56.93 (48.64-65.23)	68.99 (61.78-76.20)	55.32 (41.11-69.53)	68.99 (61.78-76.20)
4.00	81.72 (73.87-89.58)	74.05 (67.22-80.89)	65.85 (51.34-80.37)	74.05 (67.22-80.89)	49.64 (41.26-58.01)	74.05 (67.22-80.89)	48.94 (34.64-63.23)	74.05 (67.22-80.89)

M2-PK: M2-pyruvate kinase.