Colorectal cancer screening in patients at moderately increased risk due to family history

Table 2 Relative risk of colorectal cancer occurrence in a proband associated with different constellations of family history[33]

No. of FDRs with CRC	No. of SDRs with CRC	No. of TDRs with CRC	Relative risk (95% CI)
1	0	0	1.76 (1.63-1.89)
2	-	-	3.01 (2.66-3.38)
0	2	-	1.20 (1.05-1.38)
1	1	-	2.12 (1.90-2.35)
1	2	-	2.31 (1.80-2.93)
0	1	2	1.33 (1.13-1.55)

FDR: First-degree relative; SDR: Second- degree relative; TDR: Third- degree relative; CI: Confidence interval; CRC: Colorectal cancer.