Patients with hematological malignancies and serological signs of prior resolved hepatitis B

doi:10.4251/wjgo.v4.i3.37

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Mar 15, 2012 (publication date) through Nov 27, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Mar 15, 2012; 4(3): 37-45
Published online Mar 15, 2012. doi: 10.4251/wjgo.v4.i3.37

Table 1 Main characteristics of hepatitis B virological categories

Definition	Serum HBsAg	Serum transaminases	Serum antibody pattern	Serum HBVDNA (IU/mL)	Liver tissue HBVDNA
Active Carrier¹	Positive	Persistently or intermittently increased	Anti-HBs negative	> 2000	Positive
		Persistently or intermittently increased	Anti-HBc positive
Inactive Carrier²	Positive	Persistently	Anti-HBs negative	Negative or < 20 000⁴	Positive
		Normal³	Anti-HBc positive
Anti-HBc positive⁵	Negative	Persistently	Anti-HBs positive/negative	Negative (> 90%)	Positive
		Normal³	Anti-HBc positive

¹> 90% have relevant liver damage;

²> 90% do not have relevant liver damage;

³In the absence of other causes of liver damage;

⁴Currently some experts suggest a cut off of < 2000 IU/mL;

⁵Without liver damage in the absence of other causes of chronic hepatitis and/or with a previous history of chronic hepatitis B. HBsAg: Hepatitis B surface antigen; Anti-HBc: Antibody to hepatitis B core antigen; Anti-HBs: Antibody to hepatitis B surface antigen; HBVDNA: Hepatitis B virus deoxyribonucleic acid. From Marzano et al[2], adapted.

Citation: Marignani M, Gigante E, Begini P, Marzano A, di Fonzo M, Deli I, Gallina S, Cox MC, Delle Fave G. Patients with hematological malignancies and serological signs of prior resolved hepatitis B. World J Gastrointest Oncol 2012; 4(3): 37-45
URL: https://www.wjgnet.com/1948-5204/full/v4/i3/37.htm
DOI: https://dx.doi.org/10.4251/wjgo.v4.i3.37