Aberrant crypt focus and fragile histidine triad protein in sporadic colorectal carcinoma

Table 7 Fhit intensity in hyperplastic aberrant crypt focus, dysplastic aberrant crypt focus and carcinoma vs tumor differentiation

Tumor grade	Hyperplastic ACF (P = 0.719)				Dysplastic ACF (P = 0.232)				Carcinoma (P = 0.444)
Fhit→	+	++	+++	Total	+	++	+++	Total	-ive	+	++	+++	Total
Well diff		3		3	3			3	7	3			10
Mod diff	15	18	27	60	6	9	6	21	3	9	15	27	54
Poorly diff	3	6	3	12					2	6	3		11
Total	18	27	30	75	9	9	6	24	12	18	18	27	75

Fragile histidine triad (Fhit) protein grading: + = weak; ++ = moderate; +++ = strong; diff = differentiation; mod = moderate. ACF: Aberrant crypt focus.