Association between IRS-2 G1057D polymorphism and risk of gastric cancer

Table 4 Associations between variant IRS-2 genotypes and clinicopathological characteristics of gastric cancer

Variable	GD + DD	GG	Crude OR (95% CI)	P value	Adjusted OR1 (95% CI)	P value
Tumor differentiation
Well	15	6	1		1
Moderate	80	35	0.91 (0.33-2.55)	0.864	0.95 (0.33-2.76)	0.921
Poor	29	25	0.46 (0.16-1.38)	0.166	0.38 (0.11-1.35)	0.135
Depth of tumor infiltration
T1	21	14	1		1
T2	20	5	2.67 (0.81-8.77)	0.106	2.70 (0.70-10.47)	0.150
T3	60	26	1.54 (0.68-3.49)	0.302	1.46 (0.60-3.52)	0.401
T4	24	22	0.73 (0.30-1.77)	0.483	0.73 (0.29-1.86)	0.507
Lymph node metastasis
Negative	47	23	1		1
Positive	78	43	0.89 (0.48-1.65)	0.708	0.94 (0.49-1.77)	0.837
Localization
Cardia	27	15	1		1
Non-cardia	101	54	1.04 (0.51-2.12)	0.916	1.08 (0.51-2.29)	0.838

¹Adjusted for age, sex, smoking status, residence, hypertension and diabetes. OR: Odds ratio.