Association between IRS-2 G1057D polymorphism and risk of gastric cancer

Table 3 Stratified analyses for variant IRS-2 genotypes in cases and controls n (%)

Variable	(GD + DD)/GG		Crude OR (95% CI)	P value	Adjusted OR1 (95% CI)	P value
	Cases	Controls
Age (median) (yr)
≤ 58	53 (26.9)/40 (20.3)	46 (29.5)/39 (25.0)	1.29 (0.71-2.33)	0.412	1.10 (0.59-2.05)	0.762
> 58	69 (35.0)/35 (17.8)	46 (29.5)/25 (16.0)	1.22 (0.64-2.32)	0.538	1.15 (0.60-2.23)	0.674
Sex
Females	28 (14.2)/17 (8.6)	21 (13.5)/17 (10.9)	1.33 (0.55-3.21)	0.521	1.13 (0.44-2.87)	0.800
Males	94 (47.7)/58 (29.4)	71 (45.5)/47 (30.1)	1.27 (0.77-2.10)	0.342	1.12 (0.67-1.87)	0.668
Smoking status
Smokers	32 (16.2)/12 (6.1)	16 (10.4)/10 (6.5)	1.88 (0.66-5.33)	0.238	1.52 (0.49-4.70)	0.467
Non-smokers	90 (45.7)/63 (32.0)	75 (48.7)/53 (34.4)	1.16 (0.72-1.87)	0.550	1.00 (0.61-1.65)	0.990
Residence
Urban	73 (37.1)/40 (20.3)	51 (33.1)/33 (21.4)	1.44 (0.80-2.61)	0.226	1.30 (0.70-2.42)	0.406
Rural	49 (24.9)/35 (17.8)	41 (26.6)/29 (18.8)	1.04 (0.55-1.98)	0.905	0.89 (0.46-1.75)	0.743

¹Adjusted for age, sex, smoking status, residence, hypertension and diabetes. OR: Odds ratio.