Association between IRS-2 G1057D polymorphism and risk of gastric cancer

Table 2 Distribution of the IRS-2 genotype in cases and controls and risk estimates n (%)

IRS-2 genotype	Cases1	Controls1	Crude OR (95% CI)	P value	Adjusted OR2 (95% CI)	P value
Overall	197	156
GG	69 (35.02)	64 (41.03)	1.00		1.00
GD	98 (49.75)	82 (52.56)	1.11 (0.71-1.74)	0.653	0.96 (0.60-1.53)	0.864
DD	30 (15.23)	10 (6.41)	2.78 (1.26-6.15)	0.011	2.32 (1.03-5.23)	0.042
GD + DD	128 (64.98)	92 (58.97)	1.29 (0.84-1.99)	0.248	1.11 (0.71-1.75)	0.637
G allele	236 (59.90)	210 (67.31)	1.00
D allele	158 (40.10)	102 (32.69)	1.38 (1.01-1.88)	0.043

¹Distribution of the insulin receptor substrate-2 (IRS-2) genotype in cases and controls were in Hardy-Weinberg equilibrium (P = 0.204, P = 0.425, respectively);

²Adjusted for age, sex, smoking status, residence, hypertension and diabetes. OR: Odds ratio.