Intracellular chloride regulates the G1/S cell cycle progression in gastric cancer cells

doi:10.4251/wjgo.v3.i8.119

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Aug 15, 2011 (publication date) through Nov 7, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Aug 15, 2011; 3(8): 119-122
Published online Aug 15, 2011. doi: 10.4251/wjgo.v3.i8.119

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Figure 3 Roles of the intracellular chloride concentration in cell cycle progression of gastric cancer cells. The intracellular chloride concentration ([Cl^-]_i) affects the cell proliferation via activation of p38 and/or JNK cascades through upregulation of the p21. The decrease of the [Cl^-]_i causes the G₀/G₁ phase arrest by diminishing expression of CDK2 and phosphorylated Rb due to an increase in expression of p21.

Citation: Shiozaki A, Otsuji E, Marunaka Y. Intracellular chloride regulates the G₁/S cell cycle progression in gastric cancer cells. World J Gastrointest Oncol 2011; 3(8): 119-122
URL: https://www.wjgnet.com/1948-5204/full/v3/i8/119.htm
DOI: https://dx.doi.org/10.4251/wjgo.v3.i8.119