Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer

Table 2 Polymorphisms of tissue inhibitor of matrix metalloproteinases in esophageal cancer

Gene	SNP	Reference	Cancer type	Ethnicity	Case/control	Outcome parameter	Results	Parameter OR	OR	95% CI	P value
MMP-1	-1607 1G/2G	Bradbury[33]	EA	Caucasian	313/455	Cancer risk	Increased cancer risk in 1G/2G and 2G/2G	2G/2G vs 1G/1G	1.83	1.2-2.8	0.005
						Overall survival	No difference in overall survival
		Fruh[32]	EA	Caucasian	101/101	Cancer risk	No difference in cancer risk
		Jin[42]	ESCC	Chinese	234/350	Cancer risk	No difference in cancer risk
						LN metastases	No difference in LN metastases
MMP-2	-735 C/T	Li[39]	ESCC	Chinese	335/624	Cancer risk	No difference in cancer risk
		Yu[15]	ESCC	Chinese	527/777	Cancer risk	Increased cancer risk in CC (trend)	CC vs CT+TT	1.30	1.04-1.63	0.056
		Sun[31]	ESCC	Chinese	335/624	Cancer risk	No difference in cancer risk
		Chen[40]	ESCC	Mongolian	188/324	Cancer risk	Increased cancer risk in TT	TT vs CC	4.82	1.59-14.60
MMP-2	-1306 C/T	Fruh[32]	EA	Caucasian	101/101	Cancer risk	No difference in cancer risk
						Cancer risk and HP	HP infection protects against EA in CC	CC vs CT+TT	0.29	0.1-0.7
		Chen[40]	ESCC	Mongolian	188/324	Cancer risk	No difference in cancer risk
		Li[39]	ESCC	Chinese	335/624	Cancer risk	Increased cancer risk in CC	CC vs CT+TT	1.57	1.10-2.23	0.010
		Yu[15]	ESCC	Chinese	527/777	Cancer risk	Increased cancer risk in CC	CC vs CT+TT	1.52	1.17-1.96	0.001
		Sun[31]	ESCC	Chinese	335/624	Cancer risk	Increased cancer risk in CC	CC vs CT+TT	1.57	1.10-2.23
MMP-3	-1171 6A/5A	Bradbury[33]	EA	Caucasian	313/455	Cancer risk	Increased cancer risk in 6A/5A and 5A/5A	5A/5A vs 6A/6A	1.61	1.0-2.5	0.030
						Overall survival	No difference in overall survival
		Fruh[32]	EA	Caucasian	101/101	Cancer risk	No difference in cancer risk
						Cancer risk and HP	HP infection protects against EA in 6A/6A	6A/6A vs 5A/5A + 5A/6A	0.04	0.002-0.9	0.040
		Zhang[44]	ESCC	Chinese	234/350	Cancer risk	No difference in cancer risk
						Cancer in smoker	Increased cancer risk in 5A allele in smokers	5A/5A + 5A/6A vs 6A/6A	1.95	1.08-3.53
						LN metastases	Increased risk of LN metastases in 5A allele	5A/5A vs 6A/6A	2.24	1.07-4.69	0.030
						Infiltration depth	No difference in infiltration depth
MMP-3	Lys45Glu	Ouyang [16]	ESCC	Chinese	227/378	Cancer risk	No difference in cancer risk
MMP-7	-181 A/G	Zhang et al[45]	ESCC	Chinese	258/350	Cancer risk	Increased cancer risk in AG and GG	AG+GG vs AA	1.83	1.12-2.99
						LN metastases	No difference in LN metastases
MMP-9	R279Q	Wu [13]	ESCC	Chinese	132/132	Cancer risk	No difference in cancer risk
MMP-9	P574R	Wu et al[13]	ESCC	Chinese	132/132	Cancer risk	Increased cancer risk in RR	RR vs PP	4.08	1.58-10.52	0.000
MMP-9	R668Q	Wu et al[13]	ESCC	Chinese	132/132	Cancer risk	No difference in cancer risk
MMP-9	-1562 C/T	Xia et al[43]	ESCC	Chinese		Cancer risk	No difference in cancer risk
MMP-12	-82 A/G	Bradbury et al[33]	EA	Caucasian	313/455	Cancer risk	No difference in cancer risk
						Overall survival	No difference in overall survival
		Fruh et al[32]	EA	Caucasian	101/101	Cancer risk	No difference in cancer risk
						Cancer risk and HP	HP infection protects against EA in AA	AA vs AG/GG	0.44	0.2-0.8	0.020
MMP-12	1082 A/G	Bradbury et al[33]	EA	Caucasian	313/455	Cancer risk	No difference in cancer risk
						Overall survival	No difference in overall survival
MMP-12	-82 A/G	Li et al[39]	ESCC	Chinese	335/624	Cancer risk	No difference in cancer risk
						Cancer risk	No difference in cancer risk
MMP-13	-77 A/G	Zhang et al[41]	ESCC	Chinese	316/609	Cancer risk	No difference in cancer risk

SNP: Single nucleotide polymorphism; EA: Esophageal adenocarcinoma; ESCC: Esophageal squamous cell carcinoma; LN: Lymph node; HP: Helicobacter pylori; OR: Odds Ratio; 95% CI: 95% confidence interval.